Cellular changes in the enteric nervous system during ageing

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Changes in the enteric nervous system and surrounding cells during ageing

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Age-Related Changes in the Enteric Nervous System

As we enter the 21 century, the segment of the population that is the most rapidly expanding is that comprised of individuals 85 years of age and older. Dysfunctions of the gastrointestinal (GI) system, including dysphagia, constipation, diarrhea, and irritable bowel syndrome are more common complaints of the elderly, yet our knowledge of the aging GI tract is incomplete. Compared to the rapid ...

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The enteric nervous system.

T HE enteric nervous system is a collection of neu-rons in the gastrointestinal tract 1 that constitutes the " brain of the gut " and can function independently of the central nervous system. 2 This system controls the motility, 3,4 exocrine and endocrine secretions, 5 and microcirculation 6 of the gastrointestinal tract; it is also involved in regulating immune and inflammatory processes. 7 In...

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The human enteric nervous system.

Decades of work in animal models have demonstrated that the enteric nervous system (ENS) plays a key role in controlling gut functions. Recent advances made it possible to extend such studies to the ENS of man in health and even in disease. Such studies have already provided new insights into the pathophysiology of inflammatory and possibly functional bowel diseases. Studies on human ENS reveal...

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Gaseous Mediators in the Enteric Nervous System

The enteric nervous system is an independent nervous system that controls vital gut functions including motility and secretion. Enteric neurons use a variety of neurotransmitters to modulate neural as well as muscle and epithelial activity. Among them are three gaseous mediators which are nitric oxide (NO), carbon monoxide (CO) and hydrogen sulphide (H2S). All three have potent inhibitory effec...

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ژورنال

عنوان ژورنال: Developmental Biology

سال: 2013

ISSN: 0012-1606

DOI: 10.1016/j.ydbio.2013.03.015